PARP1/2-IN-3 - CAS 3032451-58-1

PARP1/2-IN-3 (Compound 29) is an orally effective inhibitor of PARP1 and PARP2, exhibiting IC50 values of 0.2235 nM and <0.001 nM, respectively. It inhibits the proliferation of Capan-1 wild-type, AZD2281-resistant, and BMN673-resistant cells, with IC50 values ranging from 1.82 to 9.98 nM. Furthermore, PARP1/2-IN-3 demonstrates anti-tumor activity in mice.

3032451-58-1

C26H21FN6O3

484.48

O=C1NN=C(C=2C=CC=CC12)CC3=CC=C(F)C(=C3)C(=O)N4CC5=NN=C(C=6OC(=CC6)C)N5CC4

-20°C

Ice Packs

Small Compound