PARP1-IN-37 - CAS 952474-39-4

PARP1-IN-37 (Compound 8) is an orally active and selective inhibitor of poly (ADP-ribose) polymerases 1 and 2 (PARP1/2), with an IC50 value of 24 nM for PARP1. It inhibits PARP activity in cells with an EC50 value of 3.7 μM and holds potential for research on BRCA-mutated tumors, such as breast and ovarian cancers.

PARP

DNA Damage/DNA Repair, Chromatin/Epigenetic

952431

C14H11N3O

237.257

O=C(N)C1=CC=CC2=CN(N=C21)C=3C=CC=CC3

-20°C

Ice Packs

Small Compound