PARP14 inhibitor 2 - CAS 3064731-00-3

PARP14 inhibitor2 (Compound 3) is an orally active and highly selective PARP14 inhibitor with an IC50 value of less than 30 nM. It effectively inhibits the mono ADP-ribosyltransferase activity of PARP14 and modulates IFN-γ and IL-4 signaling, thereby reversing pro-tumor macrophage polarization and suppressing anti-tumor inflammatory responses. PARP14 inhibitor2 holds potential for research in PARP14-related conditions such as tumors, atopic dermatitis, and autoimmune diseases.

PARP

Chromatin/Epigenetic, DNA Damage/DNA Repair

3064731-00-3

C25H32FN3O4S

489.6

O=C1N=C(NC2=CC(OCC34CCC(NC(=O)C)(CC3)CC4)=CC(F)=C12)CSC5CCOCC5

-20°C

Ice Packs

Small Compound