PAT-048 - CAS 1359983-15-5

PAT-048 is an effective and selective autotaxin inhibitor. PAT-048 reduces dermal fibrosis in vivo. PAT-048 also inhibits IL-6 mRNA expression but displays no effect on autotaxin protein and pulmonary lysophosphatidic acid (LPA) production in the lung fibrosis model. PAT-048 has an IC50 and IC90 of 20 nM and 200 nM for autotaxin in mouse plasma.

PDE

Metabolism

1359963

C22H18ClF2N3O2S

461.91

CC=1N(C=2C(C1SC3=C(F)C(C(O)=O)=CC=C3)=CC=C(Cl)C2F)C4=CN(CCC)N=C4

-20°C

Ice Packs

Small Compound