PB28 - CAS 172906-90-0

PB28 is a cyclohexylpiperazine derivative that functions as a potent and highly selective agonist of the sigma 2 (σ2) receptor, exhibiting a Ki (binding affinity) of 0.68 nM. At the same time, PB28 acts as an antagonist of the sigma 1 (σ1) receptor, with a Ki of 0.38 nM. PB28 demonstrates a lower affinity for other receptors. It effectively inhibits electrically evoked twitch in both the guinea pig bladder (EC50 value of 2.62 μM) and ileum (EC50 value of 3.96 μM) . Moreover, PB28 exhibits the ability to modulate protein-protein interaction between SARS-CoV-2 and human cells. Additionally, PB28 triggers caspase-independent apoptosis and possesses significant antitumor activity.

Others, Apoptosis, Sigma receptor, SARS-CoV

Apoptosis, Others, GPCR/G Protein, Microbiology/Virology

172816

C24H38N2O

370.581

COc1cccc2C(CCCN3CCN(CC3)C3CCCCC3)CCCc12

-20°C

Ice Packs

Small Compound