PBD dimer-4 - CAS 1821339-88-1

PBD dimer-4 (Compound 7) is a C1-substituted PBD dimer. This compound exhibits high DNA-binding affinity, effective DNA cross-linking ability, and potent cytotoxicity against MDA-MB-231 cells (IC50: 236 nM) . PBD dimer-4 serves as a payload in the ADC drug Loncastuximab tesirine, utilized for treating various cancer types.

Others, DNA Alkylator/Crosslinker

Others, DNA Damage/DNA Repair

1821250

C31H36N4O8

592.64

O(CCCO[C@@H]1[C@@]2(N(CC1)C(=O)C=3C(N=C2)=CC(OC)=C(OC)C3)[H])[C@@H]4[C@@]5(N(C(=O)C=6C(N=C5)=CC(OC)=C(OC)C6)CC4)[H]

-20°C

Ice Packs

Small Compound