PBRM1-BD2-IN-5 - CAS 2819989-61-0

PBRM1-BD2-IN-5 is a potent inhibitor of the PBRM1 Bromodomain, with dissociation constant (Kd) values of 1.5 μM and 3.9 μM for PBRM1-BD2 and PBRM1-BD5 respectively, and an inhibitory concentration 50 (IC50) value of 0.26 μM for PBRM1-BD2. This compound effectively diminishes the interaction between full-length PBRM1 and acetylated histone peptide within the PBAF complex in cell lysates, making it a promising candidate for anticancer research.

Epigenetic Reader Domain

Chromatin/Epigenetic

2819928

0.9955

C15H13ClN2O

272.73

O=C1C=2C(NC(N1)C3=CC(C)=CC=C3)=CC=CC2Cl

-20°C

Ice Packs

Small Compound