PCS1055 dihydrochloride - CAS 361979-40-0

PCS1055 dihydrochloride is an effective, selective, and competitive muscarinic M4 receptor antagonist (IC50: 18.1 nM and a Kd: 5.72 nM) . PCS1055 dihydrochloride is also a potent AChE inhibitor (IC50 s: 22 nM and 120 nM for electric eel and human AChE, respectively) . PCS1055 dihydrochloride inhibits radioligand [3H]-NMS binding to the M4 receptor (Ki: 6.5 nM) . PCS1055 dihydrochloride shows >100-fold selectivity over M1-, M3-, and M5-receptors and 30-fold selectivity at the M2 receptor.

Cholinesterase (ChE), AChR, Others

Others, Neuroscience

361939

C27H34Cl2N4

485.49

C1(N=NC(NCCC2CCN(CC2)CC3=CC=CC=C3)=C4)=C4CCCC5=CC=CC=C15.Cl.Cl

-20°C

Ice Packs

Small Compound