PD-1/PD-L1-IN 6 - CAS 2393983-76-9

PD-1/PD-L1-IN 6 (compound A13) is a potent inhibitor of PD-1/PD-L1 interaction (IC50 = 132.8 nM) with outstanding immunoregulatory activity. In a Hep3B/OS-8/hPD-L1 and CD3 T cell co-culture model, PD-1/PD-L1-IN 6 significantly elevates interferon-γ secretion without significant toxic effects. Additionally, in a T cell-tumor co-culture model, PD-1/PD-L1-IN 6 restores the immune response.

Others, PD-1/PD-L1

Others, Immunology/Inflammation, Apoptosis, Cell Cycle/Checkpoint

2393898

C25H26N2O3

402.49

C(=O)(N1C=2C(=C(C=CC2)C3=CC=CC=C3)CC1)C4=CC(OC)=C(CNCCO)C=C4

-20°C

Ice Packs

Small Compound