PD-L1-IN-3 - CAS 2953044-29-4

PD-L1-IN-3 (Compound 4a) functions as an inhibitor of the PD-1/PD-L1 axis, with an IC50 value of 4.97 nM for PD-L1 inhibition and an EC50 value of 2.70 μM for Jurkat T cell modulation. It antagonizes the PD-1/PD-L1 interaction by binding to the PD-L1 dimer, obstructing PD-1 signaling. This compound is utilized in research pertaining to lung cancer and melanoma [1].

PD-1/PD-L1

Cell Cycle/Checkpoint, Immunology/Inflammation, Apoptosis

2953011

0.9947

C19H15ClFN2OS

373.85

[Cl].N#CC1=C(OCC2=CC=C(C=C2)CN)SC=C1C=3C=CC(F)=CC3

-20°C

Ice Packs

Small Compound