PD-L1-IN-7 - CAS 3024733-03-4

PD-L1-IN-7 (compound CB31) serves as a PD-L1 inhibitor, effectuating PD-L1 internalization and retention within cells. It restrains the PD-1/PD-L1 interaction (IC 50: 0.2 nM), alters glycosylation patterns, and facilitates PD-L1 degradation. Additionally, PD-L1-IN-7 enhances T cell infiltration, boosts T cell function, and augments the capacity to destroy tumor cells.

PD-1/PD-L1

Cell Cycle/Checkpoint, Immunology/Inflammation, Apoptosis

3024733-03-4

C46H50N6O7

798.93

CC1=C(C2=C3C(N(N=C3)C4=CC(OC)=C(CN(C)[C@H]5[C@@H](O)COCC5)C(OC)=C4)=CC=C2)C=CC=C1C=6OC=7C(N6)=CC(CN(C)[C@@H]8CC[C@@H](C(O)=O)CC8)=CC7C#N

-20°C

Ice Packs

Small Compound