PD-L1/Nampt-IN-1 - CAS 3054043-85-2

PD-L1/Nampt-IN-1 is an orally active inhibitor that targets both PD-L1 and NAMPT (nicotinamide phosphoribosyltransferase), with IC50 values of 63 nM and 582 nM, respectively. It exhibits cross-species affinity, with KD values of 52.6 nM for hPD-L1 and 49.1 nM for mPD-L1. This compound effectively suppresses tumor growth by activating the tumor immune microenvironment and is applicable in melanoma research.

NAMPT, PD-1/PD-L1

Apoptosis, Metabolism, Cell Cycle/Checkpoint, Immunology/Inflammation

3053956

C28H28N4O2

452.55

O=C(NCCNCC=1C=CC(=NC1OC)C=2C=CC=C(C=3C=CC=CC3)C2C)C=4C=NC=CC4

-20°C

Ice Packs

Small Compound