PD-L1/VISTA-IN-1 - CAS 2978623-09-3

PD-L1/VISTA-IN-1 (Compound P17) is an orally active dual inhibitor targeting PD-L1 and VISTA. It effectively hinders the PD-1/PD-L1 interaction (IC50: 0.1492 μM) and the VISTA pathway (KD: 0.2723 μM), leading to the reactivation of T cells. Additionally, PD-L1/VISTA-IN-1 exhibits antitumor activity.

PD-1/PD-L1

Cell Cycle/Checkpoint, Apoptosis, Immunology/Inflammation

2978623-09-3

C22H24N4O4

408.45

CC1=C(C=CC=C1NC=2N=C(CN[C@H](C(O)=O)CO)C=C(OC)N2)C3=CC=CC=C3

-20°C

Ice Packs

Small Compound