PD-M6 - CAS 3058330-82-5

PD-M6 is an mTOR PROTAC degrader with a DC50 of 4.8 μM, which facilitates the ubiquitination and degradation of mTOR. It inhibits the proliferation of cancer cell lines HeLa, MCF-7, and HepG2 with IC50 values of 11.3, 2.58, and 3.23 μM, respectively, and induces autophagy. Additionally, PD-M6 specifically targets the degradation of the key protein LAMTOR1 in the mTOR signaling pathway.

MTOR, PROTACs

PI3K/Akt/mTOR signaling, PROTAC

3058243

C30H39N9O6

621.69

O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCCCCCCNC=4N=C(N=C(N4)N5CCOCC5)N6CCOCC6)C3C2=O)CC1

-20°C

Ice Packs

PROTAC