PDEδ/NAMPT IN-1 - CAS 2976498-55-0

PDEδ/NAMPT IN-1 (Compound 17d) is a dual inhibitor targeting phosphodiesterase 6 (PDE6) with a dissociation constant (KD) of 0.410 nM and nicotinamide phosphoribosyltransferase (NAMPT) with an inhibitory concentration (IC50) of 2.21 nM. It disrupts KRAS-related signaling by inhibiting NAMPT's role in the synthesis of nicotinamide adenine dinucleotide (NAD+), consequently inducing apoptosis in pancreatic cancer cells with KRAS mutations. This compound holds potential for research in KRAS-mutant pancreatic cancer.

Ras, NAMPT, Apoptosis, PDE, Kras

Apoptosis, MAPK, Metabolism

2976443

C26H30N4O4S

494.61

O=C(NC1=CC=C(C=C1)S(=O)(=O)N(CC2=CC=C(OC)C=C2)C3CCCC3)NCC=4C=NC=CC4

-20°C

Ice Packs

Small Compound