PDE1-IN-9 - CAS 2982945-41-3

PDE1-IN-9 (Compound 7a) is a selective inhibitor of phosphodiesterase 1 (PDE1), targeting PDE1C with an IC50 value of 11 nM. It effectively reduces the mRNA expression of IL-1β, IL-6, TNF-α, and iNOS, while also inhibiting the production of nitric oxide (NO) and reactive oxygen species (ROS) . Additionally, PDE1-IN-9 demonstrates good metabolic stability in rat liver microsomes.

NO Synthase, PDE

Immunology/Inflammation, Metabolism

2982901

C28H31N3O2

441.57

N#CC=1C(=O)N(C=2C=C(C=CC2C1C3CCCC3)NCC4CCOCC4)CC=5C=CC=CC5

-20°C

Ice Packs

Small Compound