PDE2 inhibitor 6 - CAS 2097493-39-3

PDE2 inhibitor6 (Compound 1) is an orally active phosphodiesterase (PDE) inhibitor, effectively inhibiting PDE2A, PDE3B, and PDE10A2 with IC50 values of 0.95 nM, 6.17 μM (pIC50=5.21), and 87.1 nM (pIC50=7.06), respectively. It modulates AMPA receptor activity, enhances synaptic plasticity, and improves learning and memory in rat models. Furthermore, PDE2 inhibitor6 possesses blood-brain barrier permeability.

PDE, iGluR

Metabolism, Membrane transporter/Ion channel, Neuroscience

2097451

C20H22F2N6O

400.425

C[C@H]1[C@H](C=2N3C(N=C(C(F)F)C2)=NC=N3)CN(C(=O)C=4C=C(C)N=C(C)C4)CC1

-20°C

Ice Packs

Small Compound