PDE4B/7A-IN-1 - CAS 2511632-25-8

Compound 22, a 5-hydroxynitrile rubber 7 receptor antagonist (5-HT1A Ki=8 nm, Kb=0.04 nm; 5-nitrile rubber 7K I=451 nm, Kb=460 nm), exhibits inhibitory activity against PDE4B/PDE7A (PDE4B IC50=80.4 μM; PDE7A IC50=151.3 μM) . It demonstrates significant passive biofilm penetration capabilities and high metabolic stability in vitro. Pharmacological assessment has revealed precognitive and antidepressant effects in rat behavioral tests, highlighting its potential therapeutic applications.

5-HT Receptor, Others, PDE

Metabolism, Others, Neuroscience, GPCR/G Protein

2511599

C25H35N3O3

425.56

O(C)C1=C(C=CC=C1)N2CCN(CCCC(NC3=CC(C(C)(C)C)=CC=C3O)=O)CC2

-20°C

Ice Packs

Small Compound