PDE5-IN-3 - CAS 2538149-57-2

PDE5-IN-3 (compound 11j) is a potent inhibitor of PDE5 (IC50: 1.57 nM) and has a moderate inhibitory effect on EGFR (IC50: 5.827 μM) . It markedly inhibits the Wnt/β-catenin pathway (IC50: 1286.96 ng/mL), induces the intrinsic apoptotic mitochondrial pathway in HepG2 cells, and exhibits significant antitumor effects.

Others, PDE, Apoptosis, EGFR, Wnt/beta-catenin

JAK/STAT signaling, Tyrosine Kinase/Adaptors, Metabolism, Others, Apoptosis, Stem Cells, Angiogenesis, Cytoskeletal Signaling

2538090

C21H14BrN5O2

448.27

O=C1C2=C(N(N=C2)C3=CC=C(Br)C=C3)NC(=N1)C=4C(OC)=NC5=C(C4)C=CC=C5

-20°C

Ice Packs

Small Compound