PDGFRα kinase-IN-2 - CAS 3066103-58-7

PDGFRαkinase-IN-2 is a potent inhibitor of PDGFR-α with an IC50 of 2.1 nM. It exhibits anticancer activity against human colon cancer HT-29 cells, with an IC50 of 1.48 μM. Additionally, PDGFRαkinase-IN-2 demonstrates anti-angiogenic properties in zebrafish models with low embryotoxicity, making it suitable for research in colon cancer and anti-angiogenesis.

PDGFR

Tyrosine Kinase/Adaptors, Angiogenesis

3066038

C24H23N5O3

429.47

O=C(NC1=CC=C(C=C1)NC=2N=CN=C3C=C(OC)C(OC)=CC32)NC4=CC=CC(=C4)C

-20°C

Ice Packs

Small Compound