Pelitrexol - CAS 446022-33-9

Pelitrexol (AG2037) is a GARFT inhibitor, which can inhibit the activity of mTORC1, reduce intracellular guanine nucleotides and block the cell cycle in the s-phase, with antiproliferative activity, and can be used in non-small cell lung cancer.

Antifolate, mTOR, DHFR

Cell Cycle/Checkpoint, DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling, Metabolism

445980

0.9803

C20H25N5O6S

463.51

O=C1C2=C(NC[C@@H](CCC=3SC(C(N[C@@H](CCC(O)=O)C(O)=O)=O)=CC3C)C2)NC(N)=N1

-20°C

Ice Packs

Small Compound