Pemetrexed disodium heptahydrate - CAS 357166-29-1

Pemetrexed disodium heptahydrate (LY231514) is an antifolate that inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinyl-adenosine 5'-monophosphate (GARMT) with K_i values of 1.3 nM, 7.2 nM, and 65 nM respectively. This inhibits the formation of precursor purine and pyrimidine nucleotides and cancer cell proliferation, making it suitable for research into pleural mesothelioma and non-small cell lung cancer (NSCLC) .

DNA/RNA Synthesis, DHFR, Autophagy, Antifolate

Autophagy, Cell Cycle/Checkpoint, Metabolism, DNA Damage/DNA Repair

357136

0.99783

C20H33N5Na2O13

597.49

O.O.O.O.O.O.O.[Na+].[Na+].Nc1nc(=O)c2c(CCc3ccc(cc3)C(=O)NC(CCC([O-])=O)C([O-])=O)c[nH]c2[nH]1

-20°C

Ice Packs

Small Compound