Pentagamavunon-1 - CAS 27060-70-4

Pentagamavunon-1 (PGV-1) is an oral Curcumin analog that effectively induces apoptosis through multiple molecular mechanisms. It primarily targets and inhibits key angiogenic factors, including cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF), which play crucial roles in mediating cell proliferation and survival. Additionally, PGV-1 possesses the ability to inhibit the activation of NF-κB, further enhancing its apoptotic effects. [1]

Others, COX, Apoptosis, NF-κB, VEGFR

Neuroscience, Tyrosine Kinase/Adaptors, Angiogenesis, Immunology/Inflammation, Others, Apoptosis, NF-κB

26986

C23H24O3

348.43

Cc1cc(\C=C2/CC\C(=C/c3cc(C)c(O)c(C)c3)C2=O)cc(C)c1O

-20°C

Ice Packs

Small Compound