Pep-20 - CAS 3056822-31-9

Pep-20 is a CD47/SIRPα blocking peptide with KD values of 2.91 μM for human CD47 and 3.63 μM for mouse CD47. It inhibits the CD47/SIRPα interaction with IC50 values of 24.56 μM for humans and 12.03 μM for mice. Pep-20 also exhibits antitumor activity.

Others

Others

3056822-31-9

C74H93N21O18

1564.66

C([C@H](NC([C@H](CC1=CC=C(O)C=C1)NC([C@@H](NC([C@@H](NC([C@H](CC=2C=3C(NC2)=CC=CC3)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC=4C=5C(NC4)=CC=CC5)NC([C@H](C)N)=O)=O)CO)=O)C)=O)[C@@H](C)O)=O)=O)CO)=O)CC(N)=O)=O)=O)C(N[C@H](C(N[C@@H](CC6=CN=CN6)C(O)=O)=O)CCCNC(=N)N)=O)C=7C=8C(NC7)=CC=CC8

-20°C

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Peptide