Perfluorotetradecanoic acid - CAS 376-06-7

Perfluorotetradecanoic acid (PFTeDA) is a PPARγ antagonist. It binds to the ligand-binding domain of human PPARγ, with an IC50 of 22.8 μM and a Kd of 157.8 μM. Perfluorotetradecanoic acid inhibits Leydig cell function by inducing oxidative stress and apoptosis (Apoptosis) . Although it stimulates corticosterone biosynthesis, it inhibits aldosterone production.

PPAR, Apoptosis

Apoptosis, Metabolism, DNA Damage/DNA Repair

376-06-7

C14HF27O2

714.11

O=C(O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F

-20°C

Ice Packs

Small Compound