Perforin-IN-2 - CAS 1567836-70-7

Perforin-IN-2, a benzosulfonamide perforin inhibitor, mitigates transplant rejection in allogeneic bone marrow or stem cell transplantation. It binds to plasma proteins with a binding rate of 99.8%. In vivo, a concentration higher than 900 μM is required for optimal perforin inhibition. Perforin-IN-2 effectively inhibits the lytic activity of recombinant perforin on Jurkat T leukemia cells, with an IC50 of 6.65 μM, and also prevents the death of K562 leukemia target cells [1].

Others

Others

1567836-70-7

C24H18N4O5S2

506.55

O=C1C=2C(=CC(C=3SC(=CC3)C=4C=C(NS(=O)(=O)C5=C(N(=O)=O)C=CC=C5)C=NC4)=CC2)CN1C

-20°C

Ice Packs

Small Compound