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PERK-IN-5 - CAS 2616821-91-9

PERK-IN-5 - CAS 2616821-91-9

MF-0037102-01

$1,796.22 USD
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Product Details

  • Bioactivity

    PERK-IN-5 is a highly selective, potent, orally active inhibitor of protein kinase R-like endoplasmic reticulum (ER) kinase (PERK), displaying inhibition with IC50 values of 2 nM for PERK and 9 nM for p-eIF2α. PERK-IN-5 significantly inhibited tumor growth in the 786-O renal cell carcinoma xenograft tumor model.

  • Target

    PERK, Others

  • Related Pathways

    Apoptosis, Others

  • CAS Number

    2616821-91-9

  • Molecular Formula

    C25H26F2N4O3

  • Molecular Weight

    468.5

  • SMILES

    CCc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(c1)C(=O)NC(C)C

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound