Pevonedistat hydrochloride - CAS 1160295-21-5

Pevonedistat hydrochloride (MLN4924 hydrochloride) is a selective and potent NEDD8 activating enzyme inhibitor (IC50: 4.7 nM) that induces apoptosis and cell cycle inhibition in cancer cells, and is used in the study of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) . Pelubiprofen has been used in the study of AML and MDS.)

NEDD8, Apoptosis

Metabolism, Apoptosis

1160269

0.9931

C21H26ClN5O4S

479.98

N(C1=C2C(N(C=C2)[C@@H]3C[C@@H](COS(N)(=O)=O)[C@@H](O)C3)=NC=N1)[C@@H]4C=5C(CC4)=CC=CC5.Cl

-20°C

Ice Packs

Small Compound