PF-03715455 - CAS 1056164-52-3

PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM) . PF-03715455 is an effective inhibitor of inhaled p38 MAPK. PF-03715455 displays some selectivity for p38α over p38β (respective IC50: 0.88 and 23 nM) . PF-03715455 has the potential for the treatment of COPD.

P38 MAPK

MAPK

1056109

C35H34ClN7O3S2

700.27

S(C1=CN2C(=NN=C2C=C1)C3=C(SCCO)C=CC=C3)C4=C(CNC(NC=5N(N=C(C(C)(C)C)C5)C6=CC(Cl)=C(O)C=C6)=O)C=CC=C4

-20°C

Ice Packs

Small Compound