PF-04418948 - CAS 1078166-57-0

PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors) . Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 μM. Inhibits PGE2-induced increases in intracellular cAMP; reverses PGE2-invoked relaxation of mouse trachea (IC50 = 2.7 nM) .

Prostaglandin Receptor

GPCR/G Protein, Immunology/Inflammation

1078166-57-0

0.9945

C23H20FNO5

409.41

COc1ccc2cc(OCC3(CN(C3)C(=O)c3ccc(F)cc3)C(O)=O)ccc2c1

-20°C

Ice Packs

Small Compound