PF-04634817 - CAS 1228111-63-4

PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy. PF-0463481 is an effective and orally active dual CCR2/CCR5 antagonist. It also has comparable human and rodent CCR2 potency (rat IC50=20.8 nM) . PF-0463481 shows 10-20 fold less rodent CCR5 potency (rat IC50=470 nM) .

CCR

Microbiology/Virology, GPCR/G Protein, Immunology/Inflammation

1228044

C25H36F3N5O3

511.58

C(=O)([C@]1([C@@H](C)C)C[C@H](N[C@@H]2[C@H](OC)COCC2)CC1)N3[C@@]4(CN([C@](C3)(C4)[H])C=5C=C(C(F)(F)F)N=CN5)[H]

-20°C

Ice Packs

Small Compound