PF-04802367 - CAS 1962178-27-3

PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay. It shows desirable central nervous system (CNS) properties and potency. It is equally effective at inhibition of the two known GSK-3 isoforms (GSK-3α and GSK-3β) with IC50 values of 10.0 and 9.0 nM in mobility shift assays, respectively.

GSK-3

Stem Cells, PI3K/Akt/mTOR signaling

1962148

0.9876

C16H16ClN5O3

361.78

COc1ccc(cc1Cl)-c1ocnc1C(=O)NCCCn1cncn1

-20°C

Ice Packs

Small Compound