PF-05139962 - CAS 1393712-18-9

PF-05139962 is a novel potent mTOR inhibitor with excellent mTOR biochemical inhibition, cellular potency, kinase selectivity and in vitro ADME properties. PF-05139962 has pS473 and pS6 cellular IC50 = 48 and 6 nM respectively. PF-05139962 has great selectivity against other receptors and kinases. No genotoxicity was observed on this compound and no more than 25% inhibiton was observed for major CYP enzymes (3A4, 1A2, 2C9, 2D6) at 3 uM. This compound has LE = 0.35 and LipE up to 6.8 which is in a very desirable range for a kinase inhibitor.

Others

Others

1393685

C21H27N5O4S

445.54

C[C@@H]1N(C2=C3C(=NC(=N2)C4=CC=C(NC(NCC)=O)C=C4)CCS(=O)(=O)C3)CCOC1

-20°C

Ice Packs

Small Compound