PF-06424439 methanesulfonate - CAS 1469284-79-4

PF-06424439 methanesulfonate, an orally administered, potent, and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM, demonstrates slow reversibility and time-dependent inhibition. It operates in a noncompetitive manner relative to the acyl-CoA substrate, marking its efficacy in targeting DGAT2.

Transferase, Acyltransferase

Metabolism

1469201

0.999

C23H30ClN7O4S

536.05

CS(O)(=O)=O.Clc1cnn(c1)C1(CC1)c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1

-20°C

Ice Packs

Small Compound