PF-06465469 - CAS 1407966-77-1

PF-06465469 is a covalent ITK inhibitor (IC50 = 2 nM) that also inhibits BTK. PF-06465469 suppresses CXCL12-mediated cell migration, decreases PD-1 and LAG-3 expression. PF-06465469 shows strong potential application in leukemia and T-cell lymphoma research.

CXCR, BTK, PD-1/PD-L1, Tyrosine Kinases, LAG-3

Autophagy, Cell Cycle/Checkpoint, Immunology/Inflammation, Tyrosine Kinase/Adaptors, Apoptosis, GPCR/G Protein, Angiogenesis

1407888

C30H33N7O2

523.63

NC1=C2C(=NN(C2=NC=N1)[C@H]3CN(C(C=C)=O)CCC3)C4=CC(C(NC5=CC(C)=C(C(C)C)C=C5)=O)=CC=C4

-20°C

Ice Packs

Small Compound