PF-06843195 - CAS 2067281-51-8

PF-06843195 is a potent and selective PI3Kα inhibitor that binds to the active site of PI3Kα and prevents it from catalyzing the conversion of PIP2 to PIP3, thereby inhibiting the activation of AKT, with anti-tumor activity in vitro and in vivo.

PI3K

PI3K/Akt/mTOR signaling

2067222

0.9801

C20H25F3N8O4

498.46

N([C@]1(CO)CN(C(OCC(F)F)=O)CC1)C=2C(F)=C(N=C(N2)N3CCOCC3)C=4C=NC(N)=NC4

-20°C

Ice Packs

Small Compound