PF-477736 2HCl - CAS 1247874-19-6

PF-477736, also known as PF-00477736, is a potent CHK1 inhibitor with potential to enhance chemotherapy. This compound inhibits CHK1, an ATP-dependent serine/threonine kinase that is a crucial component of the S/G2 checkpoint system for DNA replication monitoring. By bypassing the final checkpoint defenses against DNA damage-induced lethal effects, PF-477736 may improve the antitumor efficacy of various chemotherapeutic agents in tumor cells with inherent checkpoint deficiencies.

1247849

C22H27Cl2N7O2

492.4

O=C1C2=C3C(C=NN1)=C(C4=CN(C)N=C4)NC3=CC(NC([C@@H](C5CCCCC5)N)=O)=C2.Cl.Cl

-20°C

Ice Packs

Small Compound