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Molfinity

PF-6274484 - CAS 1035638-91-5

PF-6274484 - CAS 1035638-91-5

MF-0094310-01

$35.41 USD
$35.41 USD
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Product Details

  • Bioactivity

    PF-6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM, inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells with IC50 of 5.8 nM and 6.6 nM, respectively.

  • Target

    EGFR

  • Related Pathways

    JAK/STAT signaling, Angiogenesis, Tyrosine Kinase/Adaptors

  • CAS Number

    1035542

  • Purity

    0.9912

  • Molecular Formula

    C18H14ClFN4O2

  • Molecular Weight

    372.78

  • SMILES

    COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=C

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound