PF-7006 - CAS 2771955-09-8

PF-7006, an Mps1 kinase inhibitor, exhibits a Ki value of 0.27 nM and an IC50 value of 2.5 nM. It disrupts cell cycle checkpoints by inhibiting the catalytic activity of Mps1, reduces histone H3 levels, and shortens the duration of mitosis, thereby inducing apoptosis (Apoptosis) in cancer cells. When used in combination with Palbociclib, the tolerance of cancer cells to PF-7006 is enhanced. PF-7006 is applicable for research on breast cancer.

Kinesin, Apoptosis

Apoptosis, Cytoskeletal Signaling

2771955-09-8

C22H26N8O2

434.49

N#CC1=CNC2=NC(=NC(NC3CCOCC3)=C12)NC4=CC=C(N=C4C)N5CCOCC5

-20°C

Ice Packs

Small Compound