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Molfinity

PF-8380 - CAS 1144035-53-9

PF-8380 - CAS 1144035-53-9

MF-0109487-01

$38.41 USD
$38.41 USD
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Product Details

  • Bioactivity

    PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood) . It modulates lysophosphatidic acid (LPA) levels in vivo/vitro by directly inhibiting autotaxin; reduces LPA levels both in plasma and at the site of inflammation.

  • Target

    PDE

  • Related Pathways

    Metabolism

  • CAS Number

    1143973

  • Purity

    0.9945

  • Molecular Formula

    C22H21Cl2N3O5

  • Molecular Weight

    478.33

  • SMILES

    Clc1cc(Cl)cc(COC(=O)N2CCN(CCC(=O)c3ccc4[nH]c(=O)oc4c3)CC2)c1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound