PF15 - CAS 2892631-70-6

PF15, a selective FLT3-ITD degrader, serves as a PROTAC (proteolysis targeting chimera) tethering ligands for FLT3 kinase and CRBN. It exhibits a degradation concentration 50 (DC50) of 76.7 nM and notably impedes the proliferation of FLT3-ITD-positive cells. PF15 also reduces phosphorylation levels of FLT3 and STAT5 and demonstrates efficacy in inhibiting tumor growth in mouse models, suggesting potential applications in leukemia research [1].

PROTACs, FLT

Tyrosine Kinase/Adaptors, Angiogenesis, PROTAC

2892555

C44H49N13O6

855.94

NC1=C2C(=CN(CCCCC3=CN(CCCCC(NC4=C5C(C(=O)N(C5)C6C(=O)NC(=O)CC6)=CC=C4)=O)N=N3)C2=NC=N1)C7=CC=C(NC(NC=8C=C(C(C)(C)C)ON8)=O)C=C7

-20°C

Ice Packs

PROTAC