PFK-IN-1 - CAS 735303-62-5

PFK-IN-1 (compound 1) is an inhibitor of 6-phosphofructo-1-kinase (PFK), demonstrating IC50 values of 0.41 and 0.23 μM against T. brucei and T. cruzi PFK, respectively, and an ED50 of 15.18 μg/mL for T. brucei. The compound has a half-life of 9.7 minutes in rat liver microsomes and 408 minutes in mouse liver microsomes.

Parasite

Microbiology/Virology

735236

C18H15Cl2N3O4S

440.3

O=C(NC1=CC=C(C=C1)S(=O)(=O)NC2=NOC(=C2)C)CC3=CC=C(Cl)C(Cl)=C3

-20°C

Ice Packs

Small Compound