PFM046 - CAS 3053859-57-4

PFM046 is an antagonist of the liver X receptor (LXR), effectively inhibiting the activation of LXRα and LXRβ, with IC50 values of 2.04 μM and 1.58 μM respectively. It reduces the expression of SCD1 and FASN while increasing ABCA1 expression, and demonstrates antitumor activity in mouse models.

Stearoyl-CoA Desaturase (SCD), Fatty Acid Synthase, Liver X Receptor

Metabolism

3053798

C29H42O2

422.643

C[C@@]12[C@]([C@]3([C@](CC1)([C@]4(C)C(=CC3)C[C@@H](O)CC4)[H])[H])(CC[C@@]2([C@@H]([C@H](CC5=CC=CC=C5)O)C)[H])[H]

-20°C

Ice Packs

Small Compound