PfPK6-IN-1 - CAS 2417648-94-1

PfPK6-IN-1 is a potent and selective inhibitor of PfPK6 with an IC50 value of 0.3 μM. It inhibits the formation of malarial pigment, affecting the unique heme detoxification pathway specific to the parasite, with an IC50 of 13 μM for β-hematin (βH) . PfPK6-IN-1 demonstrates rapid and broad-spectrum antimalarial properties, effective against both sensitive and drug-resistant strains of the parasite. This compound can be utilized in research on antimalarial agents.

Parasite

Microbiology/Virology

2417553

C34H41F3N8O2

650.74

O=C(NC1=NC=CC(OC=2C=CC=3N=C(NC4=CC=C(C(=C4)C(F)(F)F)CN5CCN(CC)CC5)N(C3C2)C)=C1)C6CCN(C)CC6

-20°C

Ice Packs

Small Compound