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Molfinity

PG01 - CAS 853138-65-5

PG01 - CAS 853138-65-5

MF-0014612-01

$49.62 USD
$49.62 USD
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Product Details

  • Bioactivity

    PG01 is a potent CFTR Cl-channel potentiator, effective against ΔF508 (Ka 0.3 μM), and also against E193K, G970R and G551D (CFTR mutants), with Kd values of 0.22 μM, 0.45 μM and 1.94 μM, respectively.PG01 increases ΔF508-CFTR Cl- currents upon addition of forskolin. F508-CFTR Cl-current upon addition of Forskolin, correcting the gating defect of CFTR mutants.

  • Target

    CFTR

  • Related Pathways

    Membrane transporter/Ion channel

  • CAS Number

    853068

  • Purity

    0.9987

  • Molecular Formula

    C28H29N3O2

  • Molecular Weight

    439.55

  • SMILES

    CC(C)c1ccc(NC(=O)C(N(C)C(=O)Cc2c[nH]c3ccccc23)c2ccccc2)cc1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound