PGD97 - CAS 2717490-36-1

PGD97 is a selective cyclic peptide inhibitor targeting the CAL/CFTR interaction, with its desulfurization-cyclized form exhibiting a KD value of 6 nM for the CAL PDZ domain. It shows a selectivity of at least 130-fold over the NHERF1/2 PDZ domains. PGD97 stabilizes F508del-CFTR on the cell membrane, enhancing CFTR function necessary for normal pulmonary fluid balance. This compound is applicable in cystic fibrosis research.

Chloride channel, CFTR

Membrane transporter/Ion channel

2717490-36-1

C74H111N23O14S3

1643.01

C(C=1C=2C(SC1)=CC=CC2)[C@H]3C(=O)N4[C@](C(=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]([C@@](C)(C)C)C(O)=O)=O)CCCNC(=N)N)=O)[C@@H](C)O)=O)C(C)(C)SSC[C@H](NC(C)=O)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC5=CC6=C(C=C5)C=CC=C6)C(=O)N3)(CCCC4)[H]

-20°C

Ice Packs

Peptide