PH11 - CAS 1627843-95-1

PH11 is a novel Focal Adhesion Kinase (FAK) inhibitor. PH11 restores TRAIL apoptotic pathway in PANC-1 cells through down-regulation of c-FLIP via inhibition of FAK and the phosphatidylinositol-3 kinase (PI3K) /AKT pathways. Tumor necrosis factor (TNF) -related apoptosis-inducing ligand (TRAIL) emerges as one of the most-promising experimental cancer therapeutic drugs and is currently being tested in clinical trials. However, both intrinsic and acquired resistance of human cancer cells to TRAIL-induced apoptosis poses a huge problem in establishing clinically efficient TRAIL therapies.

Others, FAK

Tyrosine Kinase/Adaptors, Cytoskeletal Signaling, Angiogenesis, Others

1627747

C22H22N6O5

450.45

N(C=1N2C(N=C(NC3=C(C(OC)=O)C=CC=C3)N1)=NC=C2)C4=CC(OC)=C(OC)C(OC)=C4

-20°C

Ice Packs

Small Compound