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PHA-767491 hydrochloride - CAS 942425-68-5

PHA-767491 hydrochloride - CAS 942425-68-5

MF-0019488-01

$42.14 USD
$42.14 USD
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Product Details

  • Bioactivity

    PHA-767491 hydrochloride (CAY-10572 hydrochloride) is an effective ATP-competitive dual Cdc7/CDK9 inhibitor (IC50: 10/34 nM) . It has ~20-fold selectivity against GSK3-β and CDK1/2, 50-fold selectivity against CDK5 and MK2, 100-fold selectivity against CHK2 and PLK1.

  • Target

    GSK-3, Apoptosis, CDK

  • Related Pathways

    Stem Cells, Cell Cycle/Checkpoint, PI3K/Akt/mTOR signaling, Apoptosis

  • CAS Number

    942352

  • Purity

    0.9992

  • Molecular Formula

    C12H12ClN3O

  • Molecular Weight

    249.69

  • SMILES

    Cl.O=C1NCCc2[nH]c(cc12)-c1ccncc1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound