Phanginin A - CAS 1011528-58-7

Phanginin A, a natural product discovered in Caesalpinia sappan Linn, activates SIK1 and inhibits gluconeogenesis in mouse primary hepatocytes. Phanginin A increases PDE4 activity and suppresses the hepatic cAMP/PKA/CREB pathway, improving metabolic disorders in ob/ob mice. It may be used in studies of type 2 diabetes.

SIK

PI3K/Akt/mTOR signaling

1011463

0.9554

C21H28O5

360.44

O[C@H]1[C@@]23[C@]([C@@](C(OC)=O)(CO1)CCC2)(CC[C@@]4([C@@]3(CC5=C([C@@H]4C)C=CO5)[H])[H])[H]

-20°C

Ice Packs

Natural Product