Phellopterin - CAS 2543-94-4

Phellopterin is a partial agonist of the central benzodiazepine receptors in vitro. Phellopterin shows a cytotoxic effect on RAW264.7 cell at the concentration from 40 to 400 μM. Phellopterin reduce TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium.

PPAR, Sirtuin, TLR, PKC, PI3K, HIV Protease, Apoptosis, Akt, ERK, GABA Receptor, Integrin, STAT

Chromatin/Epigenetic, Membrane transporter/Ion channel, JAK/STAT signaling, Neuroscience, Stem Cells, MAPK, Apoptosis, Proteases/Proteasome, Microbiology/Virology, Metabolism, PI3K/Akt/mTOR signaling, DNA Damage/DNA Repair, Immunology/Inflammation, Cytoskeletal Signaling

2445

0.9999

C17H16O5

300.31

COc1c2ccoc2c(OCC=C(C)C)c2oc(=O)ccc12

-20°C

Ice Packs

Natural Product